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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver.Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achievedin liver-directed gene transfer mediated by adeno-associated viral vectors.and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B gene therapyelements that control the FIX gene expression in these cassettes were screened for liver-specifichFIX with AAV vector may potentially contribute to the creation of an efficacious gene therapy

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract:

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specificSince many features also occur in other chronic liver diseases, these scoring systems aid evaluationcriteria for remission to include complete biochemical and histological normalization on immunosuppressive therapyLiver transplantation represents a life-saving option for patients presenting with acute liver failure

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy     immunosuppression     outcomes     hepatocellular carcinoma     liver transplantation    

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Three-dimensional conformal and intensity modulated radiation therapy for hepatocellular carcinoma:basic

Jiang Guoliang

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 129-136

Abstract: report consists of two parts: basic study and clinical trial for 3-dimensional conformal radiation therapy(3DCRT) and intensity modulated radiation therapy (IMRT) in treating hepatocellular carcinoma (HCC).Radiation induced liver disease (RILD) was the predominant complication, resulting in a mortality ofIt was critical to keep irradiation dose to normal liver in a tolerable level.Chinese HCC,has been successfully applied in a series of clinical trials.It demonstrates that radiation therapy

Keywords： 3-dimensional conformal radiation therapy     intensity modulated radiation therapy     epatocellular carcinoma     liver irradiation tolerance    

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Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 519-525 doi: 10.1007/s11783-011-0326-2

Abstract: Application of directed evolution technology may be one of the most effective ways for improving thehydrolysis mechanism by cellulase, advances in cellulases (endoglucanase and -glucosidase) improvement by directedcharacteristics (for instance, thermal stability, pH adaptability and enzyme activity), limitations of directedevolution for cellulases, and the outlook for directed evolution for cellulase.

Keywords： biohydrogen     bioethanol     cellulase     cellulose     directed evolution    

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Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 311-320 doi: 10.1631/FITEE.1400425

Abstract: latter normalizes at the level of nodes. (2) Treating undirected networks as equivalent to symmetric directednetworks, we expand the definition of gefura measures to the directed case. (3) It is shown how Brandes

Keywords： Networks subdivided in groups     Partitions     Gefura measures     Q-measures     Brokerage role     Directed and    

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Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 838-847 doi: 10.1631/FITEE.1500069

Abstract: Each agent is assumed to be governed by a second-order consensus control law corresponding to a directedThe first is concerned with directed trees, which represent the class of topology with minimum informationThe second is concerned with a more general graph that can be reduced to a directed tree by contracting

Keywords： Multi-agent systems     Controllability     Directed tree    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 699-708 doi: 10.1007/s11705-021-2093-3

Abstract: In this work, an ionic strength directed self-assembly procedure is described for the preparation of

Keywords： layer-by-layer self-assembly     single bilayer     nanofiltration membrane     desalination    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liverA total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverRLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality inpatients with HBV-related liver failure.

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 421-427 doi: 10.1007/s11684-012-0223-5

Abstract:

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsto get a regression formula for standard liver volume (SLV) and BSA.It turned out that the mean liver volume of the control group was 1 058±337 cm3.Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liverIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver

Keywords： liver volume variation     cirrhosis     acute liver failure (ALF)    

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Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 123-129 doi: 10.1007/s11684-017-0563-2

Abstract:

Liver transplantation is a conventional treatment for terminal stage liver diseases.Intestinal barrier destruction is widely observed among patients receiving liver transplant and sufferingThis article reviews the research progress for gut microbial alterations and liver transplantation.microbial alteration and the prediction of possible injuries utilizing microbial alteration during liverand offer a hypothesis on the utilization of microbial alteration in liver transplantation.

Keywords： gut microbial balance     liver transplantation     ischemia–reperfusion     acute rejection    

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Title Author Date Type Operation

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Three-dimensional conformal and intensity modulated radiation therapy for hepatocellular carcinoma:basic

Jiang Guoliang

Journal Article

Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Journal Article

Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Journal Article

Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Journal Article

Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Journal Article